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A spoonful of beef brisket casserole
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5 from 3 votes

Brisket with Mac & Cheese

Slow cooked brisket covered with Mac & Cheese may be my new favorite comfort food.  Tender beef and the creamiest pasta, these flavors work great together. A make ahead dish your family will love
Prep Time6 hrs 15 mins
Cook Time15 mins
Course: entree
Cuisine: American
Keyword: brisket
Servings: 10
Calories: 725kcal



  • 2-3 lbs brisket
  • 1 onion sliced
  • 2 cloves garlic smashed
  • 3 cups beef broth divided
  • 1 cup red wine
  • ½ cup tomato paste
  • 1 teaspoon dry mustard
  • 1 teaspoon salt
  • ½ teaspoon pepper


  • 3 tablespoons butter
  • ¼ cup flour
  • 3 cups half and half
  • 12 ounces evaporated milk
  • 2 ½ cups sharp white cheddar cheese shredded
  • 1 cup mozzarella cheese shredded
  • 1 cup monterey jack cheese shredded
  • 1 lb macaroni cooked
  • 1 tablespoon fresh thyme
  • 1 teaspoon salt
  • 1 teaspoon dry mustard


  • Place onion and garlic in the bottom a slow cooker. Place brisket on top and cover with 2 cups of beef broth. Cook on high for 6 hours. Remove and let cool slightly. Cut into bite size pieces.
  • In a skillet, add wine, 1 cup of beef broth, tomato paste, mustard, salt and pepper and bring to a boil. Reduce to low and simmer for 10 minutes until it’s reduced. Add brisket and stir to combine. Place on bottom of a 9 x 13 pan or large baking dish.
  • While the wine mixture is simmering, prepare Mac & Cheese. In a large saucepan, melt butter over medium heat. Add flour and whisk for about 2 minutes. Slowly add half and half and evaporated milk and cook until slightly thickened, about 5 minutes. Add all but 1/2 cup of the cheddar cheese to the milk mixture and stir until melted. Remove from heat and add thyme and mustard. Add salt and pepper to taste. Pour over cooked and drained pasta and stir to combine. Place on the top of the meat mixture and sprinkle with remaining cheddar cheese. Cover with aluminum foil.
  • Bake at 350º until heated through and bubbly, about 10 minutes. Remove the aluminum foil, Increase temperature to broil and cook for an additional 5 minutes until slightly browned.


Calories: 725kcal | Carbohydrates: 48g | Protein: 44g | Fat: 37g | Saturated Fat: 21g | Cholesterol: 151mg | Sodium: 1315mg | Potassium: 866mg | Fiber: 2g | Sugar: 7g | Vitamin A: 1122IU | Vitamin C: 6mg | Calcium: 542mg | Iron: 4mg